Journal Article Summary
The article investigates two methods for measuring changes in nasal airway patency—acoustic rhinometry and posterior rhinomanometry—after exposure to histamine and bradykinin, substances known to affect nasal airflow. Understanding how these substances impact nasal patency is important for diagnosing and treating conditions like allergies and asthma. The study aims to determine which method provides a more reliable and efficient assessment of nasal airway changes, which can help improve patient care.
In the study, 40 healthy volunteers were subjected to nasal challenges with histamine or bradykinin, and their responses were measured using both acoustic rhinometry and posterior rhinomanometry. The researchers found that both methods showed significant changes in nasal patency in response to the substances, indicating that they are effective for this purpose. Additionally, when participants were pre-treated with cetirizine, an antihistamine, the expected changes in nasal airflow due to histamine were blocked, demonstrating the methods' sensitivity to pharmacological interventions.
However, the study has limitations, including a small sample size and the fact that it only involved healthy individuals, which may not represent all patient populations. Readers should be aware that while both methods are effective, acoustic rhinometry may offer advantages such as being quicker and requiring less cooperation from patients. It is advisable for patients to discuss any concerns about nasal airway issues or the use of these testing methods with their healthcare provider to ensure appropriate management and treatment options.
Medication Safety Note
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Article Cited
- Austin C E, Foreman J C. Acoustic rhinometry compared with posterior rhinomanometry in the measurement of histamine- and bradykinin-induced changes in nasal airway patency.. British Journal of Clinical Pharmacology 1994. DOI: 10.1111/j.1365-2125.1994.tb04235.x. PMID: 8148216. PMCID: PMC1364706.
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