Journal Article Summary
The article investigates the preparation of compounded apixaban suspensions specifically for patients using enteral feeding tubes. This topic is important because apixaban, a medication used to prevent blood clots, is not typically available in a form suitable for administration through these tubes. By developing a formulation that can be easily prepared and is compatible with feeding tubes, the study aims to improve medication delivery for patients who rely on enteral nutrition.
In the study, researchers prepared apixaban suspensions from commercially available 5-mg Eliquis tablets, testing various compounding methods and vehicles for their effectiveness. They evaluated the flowability of the suspensions through different types of feeding tubes and found that a mixture of 50% Ora-Plus and water produced the best results. The selected formulation, containing 0.25 mg/mL of apixaban, was compatible with both polyurethane and polyvinyl chloride tubes, maintaining over 98% of the drug after passing through the tubes. Additionally, the formulation was stable for up to seven days at room temperature.
While the study provides valuable insights, there are limitations to consider. The findings are based on specific compounding methods and tube types, which may not apply universally to all patients or settings. Patients and caregivers should discuss the use of compounded apixaban suspensions with healthcare professionals to ensure safety and effectiveness, especially regarding dosing and compatibility with individual feeding tube systems.
Medication Safety Note
This journal article summary is provided for educational purposes only and is not medical advice. Always consult a licensed healthcare professional before starting, stopping, or changing any medication. Always consult a licensed healthcare professional before using a medical device.
Article Cited
- Caraballo Maria L., Donmez Seda, Nathan Kobi, Zhao Fang. Compounded Apixaban Suspensions for Enteral Feeding Tubes. Hospital Pharmacy 2017. DOI: 10.1177/0018578717720507. PMID: 29326482. PMCID: PMC5735708.
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