Amitriptyline 10 mg Tablets — Generic For Elavil — Rising Pharma

Medication Summary

Medication Summary: This section summarizes DailyMed drug label information to make the label easier to understand. It is not a substitute for the official label, pharmacist counseling, prescriber instructions, or medical advice.

Overview

Amitriptyline hydrochloride tablets are a tricyclic antidepressant used for the relief of symptoms of depression. The label notes that endogenous depression is more likely to be helped than other depressive states.

The medicine has important warnings. Antidepressants, including amitriptyline, may be associated with worsening depression, suicidal thoughts, or unusual changes in behavior, especially early in treatment or when the dose changes. Patients, families, and caregivers should watch closely for these changes and report them promptly.

Amitriptyline can also interact with many other medicines and may not be used with monoamine oxidase inhibitors (MAOIs). The label also warns about serotonin syndrome, heart rhythm effects, seizure risk, glaucoma, urinary retention, and increased sensitivity in older adults. It is not approved for pediatric use and is not recommended for patients under 12 years of age.

Storage Information

Protect the patient's airway, establish an intravenous line and initiate gastric decontamination. Store at 20º to 25ºC (68º to 77ºF); excursions permitted to 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature].

Key Counseling Points

• Take amitriptyline exactly as prescribed.
• Do not use it with MAO inhibitors; the label requires a 14-day gap when switching from an MAOI.
• Tell your prescriber about all other medicines, including SSRIs/SNRIs, triptans, tramadol, lithium, buspirone, St. Johnu2019s Wort, linezolid, and intravenous methylene blue.
• Watch for new or worsening depression, suicidal thoughts, agitation, irritability, unusual behavior changes, or mania, especially early in treatment or after dose changes.
• Get urgent help if symptoms of serotonin syndrome occur, such as agitation, hallucinations, fever, sweating, fast heartbeat, tremor, stiffness, or diarrhea.
• Use caution with alcohol and other CNS depressants because amitriptyline can increase their effects.
• Be aware that the medicine may cause drowsiness or affect the ability to drive or use machinery.
• Tell a healthcare professional if you have glaucoma, urinary retention, seizures, heart disease, liver problems, or a history of bipolar disorder.
• Older adults may be more sensitive to side effects such as confusion, dry mouth, constipation, blurred vision, urinary retention, and falls.
• If symptoms of hyponatremia occur, such as headache, confusion, weakness, or unsteadiness, seek medical attention promptly.

Helpful Patient Education

Amitriptyline hydrochloride tablets are a prescription tricyclic antidepressant used for the relief of symptoms of depression. DailyMed labeling notes important safety information, including the need to monitor for worsening depression, suicidal thoughts, unusual behavior changes, and signs of serotonin syndrome.

This medicine has significant drug interaction and precaution warnings, including use with MAO inhibitors, other serotonergic medicines, alcohol, anticholinergic drugs, and certain heart or seizure-related conditions. It is not approved for pediatric use, and older adults may be more sensitive to side effects.

Medication Summary last generated: 2026-07-05 11:53:41