Amitriptyline 25 mg Tablets — Generic For Elavil — Unichem

Medication Summary

Medication Summary: This section summarizes DailyMed drug label information to make the label easier to understand. It is not a substitute for the official label, pharmacist counseling, prescriber instructions, or medical advice.

Overview

Amitriptyline hydrochloride tablets are a prescription antidepressant. The label says they are used for the relief of symptoms of depression, and endogenous depression may respond better than other depressive states.

The label warns that antidepressants may increase suicidal thinking or behavior in children, adolescents, and young adults, especially early in treatment or when the dose is changed. Patients should be monitored closely for worsening depression, unusual behavior changes, or suicidality.

Amitriptyline can cause serious side effects and has important drug interactions. It should not be taken with monoamine oxidase inhibitors (MAOIs), and the label warns about serotonin syndrome, heart rhythm problems, anticholinergic effects, and risks in people with glaucoma, seizure history, urinary retention, liver problems, or certain heart conditions.

Storage Information

Protect the patient's airway, establish an intravenous line and initiate gastric decontamination. Store at 20º to 25ºC (68º to 77ºF); excursions permitted to 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature].

Key Counseling Points

• Take this medicine only as prescribed, and do not use it with MAO inhibitors.
• Watch for worsening depression, suicidal thoughts, unusual behavior changes, agitation, irritability, or mania, especially early in treatment or after dose changes.
• Tell a healthcare professional right away if symptoms of serotonin syndrome occur, such as agitation, hallucinations, fast heartbeat, fever, stiffness, tremor, or diarrhea.
• Be aware that this medicine may cause drowsiness or impair thinking and physical abilities needed for driving or operating machinery.
• Avoid alcohol and use caution with other CNS depressants because the drug can increase their effects.
• Report symptoms that may suggest low sodium, such as headache, confusion, weakness, memory problems, or unsteadiness.
• Use caution if you have glaucoma, urinary retention, seizure history, heart disease, or liver problems, because the label warns these conditions may require special care.
• Do not take this medicine with cisapride, and tell your prescriber about all other medicines, including SSRIs, SNRIs, triptans, fentanyl, lithium, tramadol, buspirone, and St. John's Wort.
• Families and caregivers should monitor for day-to-day changes in mood, behavior, or suicidality and report concerns promptly.
• The label says the product is not approved for pediatric patients, and safety and effectiveness in children have not been established.

Helpful Patient Education

Amitriptyline hydrochloride tablets are a prescription tricyclic antidepressant used for the relief of symptoms of depression. According to the DailyMed label, this medicine has sedative effects and should be used with careful monitoring, especially because antidepressants may increase the risk of suicidal thoughts or behavior in younger patients.

This product information also highlights important safety topics, including serotonin syndrome, heart rhythm effects, anticholinergic side effects, drug interactions, and cautions for patients with glaucoma, seizure history, urinary retention, cardiovascular disease, or liver impairment. Patients, families, and caregivers should review the Medication Guide and follow prescriber instructions closely.

Medication Summary last generated: 2026-07-17 02:41:39