Estradiol (Estrogen) 2 mg Tablets — Generic For Estrace — TEVA

Medication Summary

Medication Summary: This section summarizes DailyMed drug label information to make the label easier to understand. It is not a substitute for the official label, pharmacist counseling, prescriber instructions, or medical advice.

Overview

Estradiol tablets are an oral estrogen medicine. The label says they contain micronized estradiol and are available in 0.5 mg, 1 mg, and 2 mg strengths. The 2 mg tablet contains FD&C Yellow No. 5 (tartrazine), which may cause allergic-type reactions in some susceptible people.

The tablets are indicated for several uses, including treatment of moderate to severe menopausal hot flashes, symptoms of vulvar and vaginal atrophy, low estrogen due to hypogonadism, castration, or primary ovarian failure, palliation of certain breast cancers and advanced prostate cancer, and prevention of osteoporosis. When used only for vaginal atrophy or only for osteoporosis prevention, the label says other options should be considered first in some patients.

The label also warns that estrogens can increase the risk of serious problems, including endometrial cancer, blood clots, stroke, heart attack, breast cancer, and gallbladder disease. Estrogens should be prescribed at the lowest effective dose for the shortest time consistent with treatment goals.

Some medicines and products may change how estradiol works, including CYP3A4 inducers such as St. John’s Wort, phenobarbital, carbamazepine, and rifampin, or inhibitors such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir, and grapefruit juice.

Key Counseling Points

• Take estradiol exactly as prescribed; the label says estrogen should be used at the lowest effective dose for the shortest duration.
• Report any unusual or persistent vaginal bleeding, since the label says this needs close clinical surveillance and evaluation.
• Get urgent medical help for possible blood clot, stroke, or heart attack symptoms; the label says estrogens should be stopped immediately if these occur or are suspected.
• Tell your healthcare provider if you have a history of breast cancer, estrogen-dependent cancer, blood clots, stroke, heart attack, liver disease, or undiagnosed abnormal genital bleeding, because these are listed as contraindications.
• If you have a uterus and are using estrogen, ask about whether a progestin is needed, since the label notes it can lower the risk of endometrial hyperplasia.
• Tell your provider about all medicines, supplements, and grapefruit juice; the label notes several CYP3A4 interactions that may change estrogen levels.
• Let your provider know if you have aspirin hypersensitivity or allergy concerns, because the 2 mg tablet contains tartrazine (FD&C Yellow No. 5).
• Seek prompt evaluation for sudden partial or complete loss of vision, or sudden proptosis, diplopia, or migraine, since these are listed as reasons to stop the drug and be examined.
• Keep regular follow-up visits and blood pressure checks, as the label advises monitoring and ongoing clinical surveillance.
• If you are taking thyroid replacement therapy, inform your provider, since estrogens may increase thyroid-binding globulin and affect dose needs.

Helpful Patient Education

Estradiol tablets are an oral estrogen medicine described in the DailyMed label for use in several estrogen-deficiency and hormone-related conditions. Label-listed uses include treatment of menopausal vasomotor symptoms such as hot flashes, vulvar and vaginal atrophy, hypoestrogenism, palliation for certain advanced cancers, and prevention of osteoporosis in selected patients.

This product carries important safety warnings and precautions in the label, including risks related to blood clots, stroke, heart attack, endometrial cancer, breast cancer, gallbladder disease, and some vision changes. The label also notes potential interactions with CYP3A4 inducers and inhibitors, and the 2 mg tablet contains FD&C Yellow No. 5 (tartrazine).

Medication Summary last generated: 2026-06-18 16:33:55