Description
Estradiol 2 mg Tablets is available by prescription only. Go ahead and place your purchase. After making payment, we will ensure that a valid prescription is received from your prescriber.
Drug Label Highlights
Source: This information is taken from the official DailyMed drug label page when available. It is provided for educational purposes and is not a substitute for pharmacist counseling, prescriber instructions, or the full official labeling.
Boxed Warning
Estrogens Increase The Risk Of Endometrial Cancer
Close clinical surveillance of all women taking estrogens is important. Adequate diagnostic measures, including endometrial sampling when indicated, should be undertaken to rule out malignancy in all cases of undiagnosed persistent or recurring abnormal vaginal bleeding. There is no evidence that the use of “natural” estrogens results in a different endometrial risk profile than “synthetic” estrogens at equivalent estrogen doses. (See WARNINGS, Malignant neoplasms, Endometrial cancer.)
Cardiovascular And Other Risks
Estrogens with or without progestins should not be used for the prevention of cardiovascular disease. (See WARNINGS, Cardiovascular disorders.)
The Women’s Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50 to 79 years of age) during 5 years of treatment with oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone acetate (MPA 2.5 mg) relative to placebo. (See CLINICAL PHARMACOLOGY, Clinical Studies.)
The Women’s Health Initiative Memory Study (WHIMS), a substudy of WHI, reported increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 4 years of treatment with oral conjugated estrogens plus medroxyprogesterone acetate relative to placebo. It is unknown whether this finding applies to younger postmenopausal women or to women taking estrogen alone therapy. (See CLINICAL PHARMACOLOGY, Clinical Studies.)
Other doses of oral conjugated estrogens with medroxyprogesterone acetate, and other combinations and dosage forms of estrogens and progestins were not studied in the WHI clinical trials and, in the absence of comparable data, these risks should be assumed to be similar. Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.
DailyMed highlights last updated: 2026-06-24 22:38:36
Medication Guide
Medication Summary
Medication Summary: This section summarizes DailyMed drug label information to make the label easier to understand. It is not a substitute for the official label, pharmacist counseling, prescriber instructions, or medical advice.
Overview
Estradiol tablets are a prescription estrogen medicine taken by mouth. The label says they are used for several conditions, including relief of moderate to severe menopausal vasomotor symptoms, symptoms of vulvar and vaginal atrophy, low estrogen states, certain cancer-related palliative uses, and prevention of osteoporosis in selected patients.
The label includes a boxed warning that estrogens increase the risk of endometrial cancer, and that women with persistent or recurring abnormal vaginal bleeding need close clinical evaluation. It also warns about increased risks of heart attack, stroke, blood clots, breast cancer, and probable dementia in some postmenopausal women in studies of hormone therapy.
Estradiol tablets should not be used in people with certain conditions, including unexplained genital bleeding, current or past breast cancer in most cases, estrogen-dependent cancer, blood clots, recent stroke or heart attack, liver disease, pregnancy, or allergy to the ingredients. The label also notes many precautions and possible drug interactions, including interactions with some CYP3A4 inducers and inhibitors.
Storage Information
Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).
Key Counseling Points
- This medicine is a prescription estradiol tablet taken by mouth.
- It is used for menopausal symptoms, low estrogen states, certain cancer-related uses, and prevention of osteoporosis in selected patients.
- The label warns that estrogens can increase the risk of endometrial cancer.
- Report any persistent or recurring abnormal vaginal bleeding for medical evaluation.
- The label warns about increased risks of heart attack, stroke, blood clots, breast cancer, and probable dementia in some studies.
- Do not use this medicine if you have any listed contraindications such as unexplained vaginal bleeding, pregnancy, liver disease, or a history of certain blood clots or cancers.
- Tell a healthcare professional about all medicines and supplements, including St. Johnu2019s Wort, rifampin, carbamazepine, grapefruit juice, and certain antibiotics or antifungals.
- The label advises using the lowest effective dose for the shortest duration consistent with treatment goals and risks.
- Blood pressure, thyroid status, and other lab effects may need monitoring as described in the label.
- The label advises that patients should receive the patient information leaflet with this medicine.
Helpful Patient Education
Estradiol tablets, USP are prescription estrogen tablets for oral use. According to the DailyMed label, they are indicated for moderate to severe menopausal vasomotor symptoms, symptoms of vulvar and vaginal atrophy, hypoestrogenism due to hypogonadism, castration, or primary ovarian failure, and for certain palliative uses in breast cancer and advanced androgen-dependent prostate cancer. They are also indicated for prevention of osteoporosis in selected postmenopausal women at significant risk.
DailyMed labeling also highlights important safety information, including boxed warnings about endometrial cancer and cardiovascular risks, along with precautions for blood clots, breast cancer, dementia in older postmenopausal women studied with hormone therapy, and drug interactions involving CYP3A4 inducers and inhibitors. This educational product information is based on the FDA label and is not a substitute for the full prescribing information.
Medication Summary last generated: 2026-07-18 02:39:22
Estradiol (Estrogen) 2 mg Tablets --- Generic For Estrace --- Ani Pharma may require patient-specific counseling based on your prescription, directions, allergies, medical history, and other medications.
This Medication Guide section is provided for general educational purposes only. It does not replace the official medication guide, patient information leaflet, counseling from your pharmacist, or medical advice from your prescriber.
Please read all information provided with your prescription. Contact Pill Pals Pharmacy or your prescriber with questions before using this medication.
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