Lisinopril 10 mg / Hydrochlorothiazide 12.5 mg Tablets — Generic For Zestoretic — SOLCO

Medication Summary

Medication Summary: This section summarizes DailyMed drug label information to make the label easier to understand. It is not a substitute for the official label, pharmacist counseling, prescriber instructions, or medical advice.

Overview

Lisinopril and hydrochlorothiazide tablets are a prescription medicine used to treat hypertension, or high blood pressure. Lowering blood pressure can help reduce the risk of fatal and non-fatal cardiovascular events, especially stroke and myocardial infarction.

This product combines two medicines: lisinopril, an ACE inhibitor, and hydrochlorothiazide, a diuretic. The label notes that the fixed-dose combination is not for initial therapy.

The label includes a boxed warning about fetal toxicity. If pregnancy is detected, the medicine should be discontinued as soon as possible because drugs that act on the renin-angiotensin system can cause injury and death to the developing fetus.

Storage Information

Storage Store at 20°C-25°C (68°F-77°F); excursions permitted to 15°C-30°C (59°F-86°F) [see USP Controlled Room Temperature]. Dispense in a well-closed container, if product package is subdivided. Store at 20°C to 25°C (68°F to 77°F) [See USP controlled room temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure.

Key Counseling Points

• This is a prescription medicine used for high blood pressure.
• It contains two active ingredients: lisinopril and hydrochlorothiazide.
• The label warns of fetal toxicity; pregnancy should be reported promptly so the medicine can be stopped as soon as possible if pregnancy is detected.
• The product is not indicated for initial therapy.
• Tell your healthcare professional about any history of angioedema, because this medicine is contraindicated in people with certain angioedema histories.
• Do not use this product with sacubitril, and do not take it within 36 hours of switching to or from sacubitril/valsartan.
• Do not coadminister aliskiren with this medicine in patients with diabetes.
• The label advises caution because low blood pressure, angioedema, cough, kidney problems, and high potassium can occur.
• Report side effects to Solco Healthcare US, LLC at 1-866-257-2597 or FDA at 1-800-FDA-1088.

Helpful Patient Education

Lisinopril and hydrochlorothiazide tablets are a prescription combination medicine used for the treatment of hypertension. The tablet pairs an ACE inhibitor with a diuretic and is described in the label as a fixed-dose combination for oral use.

DailyMed label information also highlights important safety considerations, including fetal toxicity warnings, angioedema risk, possible low blood pressure, kidney-related effects, cough, and changes in potassium. This educational page summarizes label-based information for lisinopril and hydrochlorothiazide tablets.

Medication Summary last generated: 2026-07-18 03:03:41