Journal Article Summary
The article examines the issue of constipation in individuals who are prescribed opioids, highlighting its prevalence and significance. Constipation is a common side effect of opioid use, affecting about 52% of patients with advanced cancer and up to 87% of those who are terminally ill. Understanding this issue is crucial because it can greatly impact the quality of life for patients who rely on opioids for pain management, whether due to cancer or chronic non-malignant conditions.
The authors conducted a systematic review of existing studies to evaluate the effectiveness and safety of various treatments for opioid-induced constipation, including oral laxatives, rectally applied medications, and opioid antagonists. They reviewed 23 studies and found that certain oral laxatives, such as lactulose, macrogol/electrolyte solutions, and senna, appear to be similarly effective. However, they noted that liquid paraffin is linked to severe side effects and is not recommended for long-term use. The review also indicated that while opioid antagonists can alleviate constipation, they may also reverse the pain-relieving effects of opioids, which is a significant consideration for patients.
The article acknowledges several limitations, including a lack of high-quality studies on some treatments and the potential adverse effects associated with certain interventions. Patients should be aware of these risks and discuss their options with healthcare professionals to find the most suitable treatment for their situation. It is important for patients to communicate openly about their symptoms and any concerns regarding opioid use and constipation, as this can help in managing their overall care effectively.
Medication Safety Note
This journal article summary is provided for educational purposes only and is not medical advice. Always consult a licensed healthcare professional before starting, stopping, or changing any medication.
Article Cited
- Ahmedzai Sam H, Boland Jason. Constipation in people prescribed opioids. BMJ Clinical Evidence 2010. PMID: 21718572. PMCID: PMC2907601.
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