Journal Article Summary
The article investigates the formulation of extended-release (ER) pellets for Atenolol, a medication commonly used to treat cardiovascular conditions. Atenolol is highly soluble, which presents challenges in creating a stable ER formulation that avoids rapid drug release, known as "burst release." The study aims to develop a delivery system that can effectively control the release of Atenolol over an extended period, potentially improving patient compliance and therapeutic outcomes.
To achieve this, the researchers designed 36 different formulations using various combinations of lipid and cellulose-based materials, including Carnauba wax, Glyceryl monostearate, Hydroxypropyl methylcellulose, and Ethyl cellulose. They employed techniques such as extrusion, spheronization, sintering, and compaction to create the pellets. The results indicated that specific formulations could successfully control Atenolol release for up to 12 hours, with the best-performing formulations showing minimal burst release and maintaining drug stability over time.
However, the study has limitations, including the need for further clinical validation to confirm the safety and efficacy of these formulations in real-world settings. Patients should consult healthcare professionals before making any changes to their medication regimen, especially when considering new formulations like these ER pellets. Discussing the potential benefits and risks with a doctor can help ensure that patients receive the most appropriate treatment for their cardiovascular conditions.
Medication Safety Note
This journal article summary is provided for educational purposes only and is not medical advice. Always consult a licensed healthcare professional before starting, stopping, or changing any medication.
Article Cited
- Maboos Madiha, Yousuf Rabia Ismail, Shoaib Muhammad Harris, Nasiri Iqbal, Hussain Tazeen, Ahmed Hafiza Fouzia, Iffat Wajiha. Effect of lipid and cellulose based matrix former on the release of highly soluble drug from extruded/spheronized, sintered and compacted pellets. Lipids in Health and Disease 2018. DOI: 10.1186/s12944-018-0783-8. PMID: 29885655. PMCID: PMC5994249.
Featured Pill Pals Product
Atenolol 25 mg Tablets --- Generic For Tenormin --- Rising Pharma
Atenolol 25 mg Tablets — Generic For Tenormin — Rising Pharma is available through Pill Pals Pharmacy with cash-pay pharmacy pricing and free shipping where available. Prescription required.
Request a prescription transfer and our pharmacy team will help coordinate the next step.
