Journal Article Summary
The article investigates how two common oral antihistamines, diphenhydramine and loratadine, affect tear volume, tear stability, and intraocular pressure (IOP). This topic is important because many people use antihistamines for allergies, and there are concerns about their potential drying effects on the eyes. Understanding how these medications influence eye health can help healthcare providers make better recommendations for patients experiencing dry eye symptoms.
In the study, 33 healthy participants aged 22 to 28 were given diphenhydramine, loratadine, or a placebo over six weeks, with each participant receiving all three treatments. The researchers measured tear volume using the phenol red thread test, assessed tear stability with tear breakup time (TBUT), and evaluated IOP. The results showed that diphenhydramine significantly decreased tear volume in the left eye, while no significant changes were observed in TBUT or IOP for either antihistamine. Loratadine did not appear to affect tear volume or stability, suggesting it may be a safer option for patients concerned about dry eyes.
The study has some limitations, including a small sample size and the focus on young, healthy individuals, which may not represent the broader population, especially those with existing eye conditions. Patients should discuss their use of antihistamines with healthcare professionals, particularly if they experience dry eye symptoms or have conditions like glaucoma. While diphenhydramine may not be advisable for those with dry eyes due to its drying effects, loratadine could be a safer alternative when used alongside conventional dry eye treatments.
Medication Safety Note
This journal article summary is provided for educational purposes only and is not medical advice. Always consult a licensed healthcare professional before starting, stopping, or changing any medication.
Article Cited
- Foutch Brian K., Sandberg Kyle A., Bennett Edward S., Naeger Leonard L.. Effects of Oral Antihistamines on Tear Volume, Tear Stability, and Intraocular Pressure. Vision 2020. DOI: 10.3390/vision4020032. PMID: 32575705. PMCID: PMC7355746.
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