Journal Article Summary
The article investigates a new formulation of atorvastatin calcium (ATC) designed to improve its oral bioavailability, which is typically low at only 14%. This low bioavailability is primarily due to the drug's instability and poor absorption in the intestines. Enhancing the delivery of ATC is important because it is commonly used to manage cholesterol levels and reduce the risk of cardiovascular diseases. The study aims to create a stabilized gastro-retentive floating tablet that can maintain the drug's effectiveness and improve its absorption in the body.
To conduct the study, researchers developed a specific formulation of ATC using various excipients to enhance its stability and solubility. They utilized a factorial design to optimize the formulation, which included ingredients like hypromellose and docusate sodium. The best formulation demonstrated a floating lag time of about 56 seconds and achieved a dissolution rate of 98.2% over 12 hours. In tests with rabbits, this new formulation showed a 1.6 times increase in bioavailability compared to a standard tablet, indicating that the gastro-retentive approach could significantly improve the effectiveness of ATC.
However, the study has limitations, including the use of animal models, which may not fully represent human responses. Additionally, while the new formulation shows promise, further research is needed to confirm its safety and efficacy in humans. Patients should discuss any changes to their atorvastatin treatment with a healthcare professional, especially if they are considering new formulations or delivery methods, to ensure they receive the most effective and safe treatment for their condition.
Medication Safety Note
This journal article summary is provided for educational purposes only and is not medical advice. Always consult a licensed healthcare professional before starting, stopping, or changing any medication.
Article Cited
- Khan Furquan Nazimuddin, Dehghan Mohamed Hassan G.. Enhanced Bioavailability of Atorvastatin Calcium from Stabilized Gastric Resident Formulation. AAPS PharmSciTech 2011. DOI: 10.1208/s12249-011-9673-3. PMID: 21879394. PMCID: PMC3225550.
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