Lisinopril 10 mg / Hydrochlorothiazide 12.5 mg Tablets — Generic For Zestoretic — Lupin

Medication Summary

Medication Summary: This section summarizes DailyMed drug label information to make the label easier to understand. It is not a substitute for the official label, pharmacist counseling, prescriber instructions, or medical advice.

Overview

Lisinopril and hydrochlorothiazide tablets are a fixed-dose combination medicine used to treat high blood pressure. Lowering blood pressure can help reduce the risk of serious cardiovascular events, including stroke and myocardial infarction.

This product combines lisinopril, an ACE inhibitor, with hydrochlorothiazide, a diuretic. The label states that the combination may have additive blood-pressure-lowering effects and is available in more than one strength.

The label includes a boxed warning about fetal toxicity. If pregnancy is detected, lisinopril and hydrochlorothiazide should be discontinued as soon as possible.

The medicine is not indicated for initial therapy. The label also lists important precautions and contraindications, including a history of angioedema related to ACE inhibitor use, hereditary or idiopathic angioedema, anuria, hypersensitivity to sulfonamide-derived drugs, and use with a neprilysin inhibitor such as sacubitril/valsartan.

Storage Information

Storage Store at 20° to 25°C (68° to 77°F).

Key Counseling Points

• This medicine is used to lower blood pressure.
• It contains two medicines: lisinopril and hydrochlorothiazide.
• The label warns to stop the medicine if pregnancy is detected and to contact a healthcare professional right away.
• Seek urgent help for swelling of the face, lips, tongue, throat, or trouble breathing, which may be a sign of angioedema.
• Report severe dizziness, fainting, or symptoms of low blood pressure.
• Tell the prescriber about kidney disease, liver disease, diabetes, or a history of angioedema.
• Do not use this product with sacubitril/valsartan or within 36 hours of switching to or from it.
• The label says it is not indicated for initial therapy.
• Tell a healthcare professional about all medicines and supplements being taken, including potassium supplements or potassium-containing salt substitutes.
• Use caution if vision changes or eye pain occur, since hydrochlorothiazide can cause acute myopia and angle-closure glaucoma.

Helpful Patient Education

Lisinopril and hydrochlorothiazide tablets are a combination prescription medicine used to treat hypertension, or high blood pressure. The product combines an ACE inhibitor, lisinopril, with a diuretic, hydrochlorothiazide, and the label notes that blood pressure lowering with the combination may be additive.

DailyMed label information also highlights important safety warnings and precautions, including fetal toxicity during pregnancy, angioedema, low blood pressure, kidney-related effects, and possible changes in potassium levels. This educational product information is based on the labeled uses, warnings, and precautions for lisinopril and hydrochlorothiazide tablets.

Medication Summary last generated: 2026-07-11 03:01:44