Lisinopril 20 mg / Hydrochlorothiazide 12.5 mg Tablets — Generic For Zestoretic — SOLCO

Medication Summary

Medication Summary: This section summarizes DailyMed drug label information to make the label easier to understand. It is not a substitute for the official label, pharmacist counseling, prescriber instructions, or medical advice.

Overview

Lisinopril and hydrochlorothiazide tablets are a prescription medicine used to treat hypertension, also called high blood pressure. Lowering blood pressure can help reduce the risk of serious cardiovascular events such as stroke and heart attack.

This product combines two medicines: lisinopril, an ACE inhibitor, and hydrochlorothiazide, a diuretic. The label says the fixed-dose combination is not for initial therapy.

The label includes an important warning about fetal toxicity. If pregnancy is detected, lisinopril and hydrochlorothiazide tablets should be discontinued as soon as possible. The medicine should also not be used in people with certain allergy or angioedema histories, anuria, or with some interacting medicines listed on the label.

Storage Information

Storage Store at 20°C-25°C (68°F-77°F); excursions permitted to 15°C-30°C (59°F-86°F) [see USP Controlled Room Temperature]. Dispense in a well-closed container, if product package is subdivided. Store at 20°C to 25°C (68°F to 77°F) [See USP controlled room temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure.

Key Counseling Points

• Take this medicine by mouth exactly as prescribed.
• It is used to treat high blood pressure.
• Do not use it as initial therapy unless specifically directed by the prescriber, since the label says the fixed-dose combination is not indicated for initial therapy.
• Tell a healthcare professional right away if pregnancy is detected, because the label warns to stop the medicine as soon as possible.
• Be aware of warning signs of angioedema such as swelling of the face, lips, tongue, glottis, or larynx.
• The label warns that excessive low blood pressure can occur, especially in volume- or salt-depleted patients.
• Report symptoms of cough, since persistent nonproductive cough has been reported with ACE inhibitors.
• This medicine may affect kidney function and potassium levels; the label notes that monitoring may be needed in some patients.
• Tell a healthcare professional about all other medicines, especially neprilysin inhibitors, aliskiren in diabetes, potassium supplements, potassium-sparing diuretics, and lithium.
• Seek prompt attention for vision changes or eye pain, which are listed as possible signs of acute myopia and angle-closure glaucoma from hydrochlorothiazide.

Helpful Patient Education

Lisinopril and hydrochlorothiazide tablets are a prescription combination medicine used for the treatment of hypertension. The product pairs an ACE inhibitor, lisinopril, with a diuretic, hydrochlorothiazide, and is available in fixed-dose tablet strengths for oral use.

This medication page is intended to help patients understand label-based information about uses, key warnings, contraindications, and important safety considerations such as pregnancy risk, angioedema, blood pressure lowering, kidney effects, and possible interactions with other medicines.

Medication Summary last generated: 2026-07-18 03:04:04