Lisinopril 20 mg / Hydrochlorothiazide 12.5 mg Tablets — Generic For Zestoretic — Lupin

Medication Summary

Medication Summary: This section summarizes DailyMed drug label information to make the label easier to understand. It is not a substitute for the official label, pharmacist counseling, prescriber instructions, or medical advice.

Overview

Lisinopril and hydrochlorothiazide tablets contain two medicines that work together to treat high blood pressure. Lisinopril is an ACE inhibitor, and hydrochlorothiazide is a diuretic, also called a water pill.

This medicine is used to lower blood pressure and may help reduce the risk of serious cardiovascular events such as stroke and heart attack. The label says these fixed-dose combination tablets are not indicated for initial therapy.

The label includes a boxed warning for fetal toxicity. If pregnancy is detected, lisinopril and hydrochlorothiazide should be discontinued as soon as possible because drugs that act on the renin-angiotensin system can cause injury and death to the developing fetus.

Important safety warnings include angioedema, low blood pressure, kidney-related effects, high potassium, and rare blood or liver problems. Hydrochlorothiazide can also cause acute myopia and secondary angle-closure glaucoma.

Storage Information

Storage Store at 20° to 25°C (68° to 77°F).

Key Counseling Points

• This medicine is used to treat hypertension, or high blood pressure.
• It contains two active ingredients: lisinopril and hydrochlorothiazide.
• The label says the combination is not for initial therapy.
• If pregnancy is detected, the medicine should be stopped as soon as possible.
• Get medical help right away for swelling of the face, lips, tongue, throat, or trouble breathing.
• Tell a clinician if you have a history of angioedema or allergic reactions to ACE inhibitors, sulfonamide-derived drugs, or neprilysin inhibitors.
• The medicine can cause low blood pressure, especially in people who are volume-depleted or taking diuretics.
• The label warns about possible kidney changes and high potassium; monitoring may be needed.
• Report severe abdominal pain, which may be a sign of intestinal angioedema.
• Report sudden decreased vision or eye pain, which may be a sign of acute angle-closure glaucoma from hydrochlorothiazide.

Helpful Patient Education

Lisinopril and hydrochlorothiazide tablets are a prescription combination medicine used to treat hypertension, or high blood pressure. The product combines an ACE inhibitor with a diuretic to help lower blood pressure and reduce the risk of cardiovascular events such as stroke and heart attack.

DailyMed labeling for this product highlights important safety information, including fetal toxicity, angioedema, low blood pressure, kidney effects, and changes in potassium levels. It also notes that the tablets are not indicated for initial therapy and that hydrochlorothiazide can rarely cause acute eye symptoms such as angle-closure glaucoma.

Medication Summary last generated: 2026-07-18 03:04:08