Lisinopril 20 mg / Hydrochlorothiazide 25 mg Tablets — Generic For Zestoretic — Lupin

Medication Summary

Medication Summary: This section summarizes DailyMed drug label information to make the label easier to understand. It is not a substitute for the official label, pharmacist counseling, prescriber instructions, or medical advice.

Overview

Lisinopril and hydrochlorothiazide tablets are a fixed-dose combination medicine used to treat high blood pressure. The label states that lowering blood pressure can help reduce the risk of serious cardiovascular events, including stroke and heart attack.

This product combines an ACE inhibitor, lisinopril, with a diuretic, hydrochlorothiazide. The combination is intended for oral use and is not indicated for initial therapy.

The label includes a boxed warning about fetal toxicity. If pregnancy is detected, lisinopril and hydrochlorothiazide should be discontinued as soon as possible.

The label also warns about possible angioedema, hypotension, changes in kidney function, hyperkalemia, and other serious reactions. Patients should be aware of symptoms that may need prompt medical attention, such as swelling of the face or throat or sudden vision changes.

Storage Information

Storage Store at 20° to 25°C (68° to 77°F).

Key Counseling Points

• This medicine is used to treat hypertension, or high blood pressure.
• It contains two medicines: lisinopril and hydrochlorothiazide.
• Do not use this medicine if you have a history of angioedema related to an ACE inhibitor, hereditary or idiopathic angioedema, or hypersensitivity to this product.
• Do not take it with sacubitril, and do not use it within 36 hours of switching to or from sacubitril/valsartan.
• If pregnancy is detected, stop the medicine as soon as possible and contact the prescriber.
• Seek prompt attention for swelling of the face, lips, tongue, glottis, or larynx, or for trouble breathing.
• Tell a healthcare professional right away about severe dizziness, fainting, or symptoms of low blood pressure.
• Report abdominal pain with or without nausea or vomiting, since intestinal angioedema has been reported with ACE inhibitors.
• Report sudden decreased vision or eye pain, which may signal acute myopia or angle-closure glaucoma from hydrochlorothiazide.
• The label notes that potassium and kidney function may need monitoring because hyperkalemia and renal effects can occur.

Helpful Patient Education

Lisinopril and hydrochlorothiazide tablets are a prescription combination used to treat high blood pressure. The product combines an ACE inhibitor with a diuretic, and the label notes that lowering blood pressure can help reduce the risk of stroke and myocardial infarction.

Educational label information also includes important safety warnings about fetal toxicity, angioedema, low blood pressure, kidney effects, potassium changes, and rare eye reactions with hydrochlorothiazide. This medicine is not indicated for initial therapy, and the label advises attention to contraindications and drug interactions.

Medication Summary last generated: 2026-07-18 03:04:14