Promethazine 25 mg Tablets — Generic For Phenergan — Zydus

Medication Summary

Medication Summary: This section summarizes DailyMed drug label information to make the label easier to understand. It is not a substitute for the official label, pharmacist counseling, prescriber instructions, or medical advice.

Overview

Promethazine hydrochloride tablets are an antihistamine medicine that can also have sedative and anti-nausea effects. The label says it is used for allergies, motion sickness, nausea and vomiting, sedation, and some allergy-related reactions.

The tablets come in 12.5 mg, 25 mg, and 50 mg strengths. Promethazine can cause drowsiness and may slow mental and physical abilities needed for driving or using machinery.

The label contains important warnings about breathing problems, especially in children under 2 years old, for whom this medicine is contraindicated. It also warns about use with other medicines or substances that can depress the central nervous system, such as alcohol, sedatives, narcotics, and some antidepressants.

Storage Information

Store at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].

Key Counseling Points

• This medicine may cause marked drowsiness or slow reaction time.
• Do not drive or operate machinery until you know how this medicine affects you.
• Avoid alcohol and be careful with other medicines that can cause drowsiness or breathing problems.
• Promethazine is contraindicated in children under 2 years of age.
• Report any trouble breathing right away; the label warns about potentially serious respiratory depression.
• Tell a healthcare professional about seizure disorders, lung problems, liver problems, glaucoma, prostate problems, or bladder problems before use.
• Use caution in children 2 years and older and in older adults, who may be more sensitive to side effects.
• Let a healthcare professional know if involuntary muscle movements, confusion, or unusual behavior occur.
• For nausea and vomiting in children, the label says antiemetics should not be used for vomiting of unknown cause and use should be limited to prolonged vomiting of known etiology.
• Protect the tablets from light and keep the container tightly closed as directed on the label.

Helpful Patient Education

Promethazine hydrochloride tablets are a prescription antihistamine available in 12.5 mg, 25 mg, and 50 mg strengths. According to the label, the medicine is used for allergy symptoms, motion sickness, nausea and vomiting, and sedation, and it may also be used in certain allergic reactions and around surgery.

This product information includes important safety warnings about drowsiness, breathing problems, and interactions with alcohol and other central nervous system depressants. The label also states that promethazine hydrochloride tablets are contraindicated in children under 2 years of age and should be used with caution in older children and adults.

Medication Summary last generated: 2026-07-19 02:56:54