Journal Article Summary
The article investigates the use of crushed delayed-release tablets (DRT) of posaconazole in children who cannot swallow pills or have enteral feeding tubes. Posaconazole is an antifungal medication used to prevent and treat serious fungal infections, but its oral suspension form often leads to inadequate drug levels in young patients. This study is important because achieving the right drug concentration is crucial for effective treatment and can significantly impact patient outcomes.
The researchers conducted a case series involving four children aged 4 to 14 years who received crushed posaconazole DRT through enteral tubes between September 2022 and April 2023. Each child was given a specific dosage, and the study found that all participants reached the target drug concentrations necessary for effective treatment or prevention of fungal infections. Notably, while no side effects were reported, two children needed a dose adjustment before achieving the desired drug levels. The use of DRT also allowed for earlier hospital discharges for some patients.
However, the study has limitations, including a small sample size and the lack of a control group, which may affect the generalizability of the findings. Patients and caregivers should discuss the use of crushed posaconazole DRT with healthcare professionals, especially regarding the appropriate dosing and monitoring of drug levels. It is essential to ensure that any changes in medication formulation are safe and effective for individual treatment plans.
Medication Safety Note
This journal article summary is provided for educational purposes only and is not medical advice. Always consult a licensed healthcare professional before starting, stopping, or changing any medication. Always consult a licensed healthcare professional before using a medical device.
Article Cited
- Weerdenburg Heather L, Gwee Amanda, Haeusler Gabrielle, Osowicki Joshua, Boast Alison. 2571. Posaconazole DRT in Children; Time to Bring Out the Pill Crusher?. Open Forum Infectious Diseases 2023. DOI: 10.1093/ofid/ofad500.2188. PMCID: PMC10678372.
Featured Pill Pals Product
Pill Pals - Pill Cutter, Crusher, Splitter, and Holder (3 in 1) --- Three in One
Pill Pals - Pill Cutter, Crusher, Splitter, and Holder (3 in 1) --- Three in One is available through Pill Pals Pharmacy with cash-pay pharmacy pricing and free shipping where available. No prescription required for eligible over-the-counter purchases.
