Journal Article Summary
The article examines the use of nonspecific immunomodulators in preventing recurrent respiratory tract infections (RTIs), wheezing, and asthma in children. This topic is important because respiratory infections are common in children and can lead to significant health issues, including asthma, which can affect their quality of life and increase healthcare costs. The authors aim to provide a comprehensive overview of both the mechanistic and clinical evidence supporting the use of these immunomodulators, which have been used empirically for many years but have gained more attention in recent research.
The authors conducted a systematic review of studies published between 1997 and 2017 that included both mechanistic and clinical data on nonspecific immunomodulators. They found that these treatments, particularly OM-85, have shown promise in reducing the incidence and severity of RTIs and wheezing in children at high risk. The review highlights that these immunomodulators work by enhancing the immune response in the respiratory system, leading to fewer infections and wheezing episodes, which could potentially lower the risk of developing asthma later in life.
However, the article also notes several limitations, including the variability in study quality and definitions of recurrent respiratory infections across different trials. It emphasizes the need for further research to establish clearer guidelines and safety profiles for these treatments. Parents and caregivers should discuss the potential benefits and risks of nonspecific immunomodulators with their healthcare providers, especially if their child has a history of respiratory issues, to make informed decisions about their use.
Medication Safety Note
This journal article summary is provided for educational purposes only and is not medical advice. Always consult a licensed healthcare professional before starting, stopping, or changing any medication.
Article Cited
- Esposito Susanna, Soto-Martinez Manuel E., Feleszko Wojciech, Jones Marcus H., Shen Kun-Ling, Schaad Urs B.. Nonspecific immunomodulators for recurrent respiratory tract infections, wheezing and asthma in children: a systematic review of mechanistic and clinical evidence. Current Opinion in Allergy and Clinical Immunology 2018. DOI: 10.1097/ACI.0000000000000433. PMID: 29561355. PMCID: PMC6037280.
Featured Pill Pals Product
Loratadine 10 mg --- 300 Count Bottle --- Generic For Claritin --- Major / Rugby
Loratadine 10 mg --- 300 Count Bottle --- Generic For Claritin --- Major Pharma is available through Pill Pals Pharmacy with cash-pay pharmacy pricing and free shipping where available. No prescription required for eligible over-the-counter purchases.
