Description
Donepezil 5 mg Tablets is available by prescription only. Go ahead and place your purchase. After making payment, we will ensure that a valid prescription is received from your prescriber.
Drug Label Highlights
Source: This information is taken from the official DailyMed drug label page when available. It is provided for educational purposes and is not a substitute for pharmacist counseling, prescriber instructions, or the full official labeling.
These highlights do not include all the information needed to use DONEPEZIL HYDROCHLORIDE TABLETS safely and effectively. See full prescribing information for DONEPEZIL HYDROCHLORIDE TABLETS.
DONEPEZIL HYDROCHLORIDE tablets, for oral use
Initial U.S. Approval: 1996
Indications And Usage
Donepezil hydrochloride is an acetylcholinesterase inhibitor indicated for the treatment of dementia of the Alzheimer's type. Efficacy has been demonstrated in patients with mild, moderate, and severe Alzheimer's Disease (1).
Dosage And Administration
Dosage Forms And Strengths
Tablets: 5 mg, 10 mg (3)
Contraindications
Known hypersensitivity to donepezil hydrochloride or to piperidine derivatives (4)
Warnings And Precautions
- Cholinesterase inhibitors are likely to exaggerate succinylcholine-type muscle relaxation during anesthesia (5.1).
- Cholinesterase inhibitors may have vagotonic effects on the sinoatrial and atrioventricular nodes manifesting as bradycardia or heart block (5.2).
- Donepezil hydrochloride can cause vomiting. Patients should be observed closely at initiation of treatment and after dose increases (5.3).
- Patients should be monitored closely for symptoms of active or occult gastrointestinal (GI) bleeding, especially those at increased risk for developing ulcers (5.4).
- Cholinomimetics may cause bladder outflow obstructions (5.6).
- Cholinomimetics are believed to have some potential to cause generalized convulsions (5.7).
- Cholinesterase inhibitors should be prescribed with care to patients with a history of asthma or obstructive pulmonary disease (5.8).
- Cholinesterase inhibitors are likely to exaggerate succinylcholine-type muscle relaxation during anesthesia (5.1).
- Cholinesterase inhibitors may have vagotonic effects on the sinoatrial and atrioventricular nodes manifesting as bradycardia or heart block (5.2).
- Donepezil hydrochloride can cause vomiting. Patients should be observed closely at initiation of treatment and after dose increases (5.3).
- Patients should be monitored closely for symptoms of active or occult gastrointestinal (GI) bleeding, especially those at increased risk for developing ulcers (5.4).
- Cholinomimetics may cause bladder outflow obstructions (5.6).
- Cholinomimetics are believed to have some potential to cause generalized convulsions (5.7).
- Cholinesterase inhibitors should be prescribed with care to patients with a history of asthma or obstructive pulmonary disease (5.8).
Adverse Reactions
Most common adverse reactions in clinical studies of donepezil hydrochloride are nausea, diarrhea, insomnia, vomiting, muscle cramps, fatigue, and anorexia (6.1).
To report SUSPECTED ADVERSE REACTIONS, contact Solco Healthcare US, LLC at 1-866-257-2597 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Drug Interactions
Use In Specific Populations
Pregnancy: Based on animal data, may cause fetal harm (8.1).
See 17 for PATIENT COUNSELING INFORMATION.
Revised: 6/2025
DailyMed highlights last updated: 2026-06-24 22:37:34
Medication Guide
Medication Summary
Medication Summary: This section summarizes DailyMed drug label information to make the label easier to understand. It is not a substitute for the official label, pharmacist counseling, prescriber instructions, or medical advice.
Overview
Donepezil hydrochloride tablets are a prescription medicine taken by mouth for the treatment of dementia of the Alzheimer's type. The label states that it has been shown to be effective in patients with mild, moderate, and severe Alzheimer’s disease.
For mild to moderate Alzheimer’s disease, the recommended starting dose is 5 mg once daily in the evening, just before retiring. The maximum recommended dose is 10 mg per day, and the label says the 10 mg dose should not be started until a patient has taken 5 mg daily for 4 to 6 weeks.
For moderate to severe Alzheimer’s disease, the recommended starting dose is also 5 mg once daily in the evening, just before retiring. Donepezil hydrochloride can be taken with or without food. The label notes that the most common side effects include nausea, diarrhea, insomnia, vomiting, muscle cramps, fatigue, and anorexia.
Storage Information
Storage Store at controlled room temperature, 15°C to 30°C (59°F to 86°F). stored? Store donepezil hydrochloride at room temperature between 59° to 86°F (15° to 30°C).
Key Counseling Points
- Take donepezil hydrochloride in the evening, just before going to bed.
- It can be taken with or without food.
- The usual starting dose is 5 mg once daily; the 10 mg dose should not be started until after 4 to 6 weeks on 5 mg daily.
- Common side effects reported in studies include nausea, diarrhea, vomiting, insomnia, muscle cramps, fatigue, and loss of appetite.
- The label says nausea, diarrhea, and vomiting may happen more often with 10 mg/day than with 5 mg/day.
- Tell a healthcare professional if vomiting occurs after starting treatment or after a dose increase, since the label advises close observation at those times.
- Donepezil hydrochloride should not be used by people with a known hypersensitivity to donepezil hydrochloride or piperidine derivatives.
- The label warns about possible heart-related effects such as bradycardia or heart block, especially in people with or without underlying conduction problems.
- The label also warns to monitor for signs of gastrointestinal bleeding, especially in people with a history of ulcers or those taking NSAIDs.
- If an overdose is suspected, the label advises contacting a Poison Control Center.
Helpful Patient Education
Donepezil hydrochloride tablets are an oral prescription medicine used for the treatment of dementia of the Alzheimer's type. The DailyMed label states that efficacy has been demonstrated in patients with mild, moderate, and severe Alzheimer’s disease. This product is supplied as film-coated tablets in 5 mg and 10 mg strengths.
Educational information on this page is based on the product label and includes dosing basics, common adverse reactions, and important safety warnings such as possible nausea, diarrhea, vomiting, bradycardia, gastrointestinal bleeding, and interactions with certain other medicines.
Medication Summary last generated: 2026-07-17 03:01:27
Donepezil 5 mg Tablets --- Generic For Aricept --- SOLCO may require patient-specific counseling based on your prescription, directions, allergies, medical history, and other medications.
This Medication Guide section is provided for general educational purposes only. It does not replace the official medication guide, patient information leaflet, counseling from your pharmacist, or medical advice from your prescriber.
Please read all information provided with your prescription. Contact Pill Pals Pharmacy or your prescriber with questions before using this medication.
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