Lisinopril 20 mg / Hydrochlorothiazide 12.5 mg Tablets — Generic For Zestoretic — SOLCO

Medication Summary

Medication Summary: This section summarizes DailyMed drug label information to make the label easier to understand. It is not a substitute for the official label, pharmacist counseling, prescriber instructions, or medical advice.

Overview

Lisinopril and hydrochlorothiazide tablets are a prescription medicine used to treat high blood pressure. Lowering blood pressure can help reduce the risk of fatal and non-fatal cardiovascular events, especially stroke and heart attack.

This product combines lisinopril, an ACE inhibitor, with hydrochlorothiazide, a diuretic. The label notes that the fixed-dose combination is not for initial therapy.

The label carries a warning for fetal toxicity. If pregnancy is detected, lisinopril and hydrochlorothiazide tablets should be discontinued as soon as possible.

Storage Information

Storage Store at 20°C-25°C (68°F-77°F); excursions permitted to 15°C-30°C (59°F-86°F) [see USP Controlled Room Temperature]. Dispense in a well-closed container, if product package is subdivided. Store at 20°C to 25°C (68°F to 77°F) [See USP controlled room temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure.

Key Counseling Points

• This is a prescription medicine for oral use.
• It is used to treat hypertension, or high blood pressure.
• The tablet combines lisinopril and hydrochlorothiazide in one product.
• The label warns that pregnancy should be reported promptly because the medicine can cause fetal toxicity.
• Do not use this product with sacubitril, and it should not be given within 36 hours of switching to or from sacubitril/valsartan.
• Do not coadminister aliskiren with this medicine in patients with diabetes.
• Tell the healthcare provider about any history of angioedema, kidney disease, liver disease, or sulfonamide allergy.
• The label notes that this medicine may cause cough, hypotension, hyperkalemia, and rare angioedema.
• If vision changes or eye pain occur, the label advises that hydrochlorothiazide can cause acute transient myopia and acute angle-closure glaucoma.
• Patients should know that the medicine may need monitoring of kidney function and serum potassium in some situations.

Helpful Patient Education

Lisinopril and hydrochlorothiazide tablets are a prescription combination medicine used for the treatment of hypertension. The product contains lisinopril, an angiotensin converting enzyme inhibitor, and hydrochlorothiazide, a diuretic. According to the label, lowering blood pressure helps reduce the risk of serious cardiovascular events such as stroke and myocardial infarction.

This DailyMed-labeled product includes important safety information about fetal toxicity, angioedema, hypotension, kidney effects, potassium changes, and eye-related adverse reactions associated with hydrochlorothiazide. Educational pharmacy content should reflect the labeled indications, contraindications, warnings, and precautions for safe use.

Medication Summary last generated: 2026-07-18 03:03:57